Heather M. Stapleton

Heather M. Stapleton

Dan and Bunny Gabel Associate Professor of Environmental Ethics and Sustainable Environmental Management

Dr. Stapleton's research focuses on understanding the fate and transformation of organic contaminants in aquatic systems and in indoor environments. Her main focus has been on the bioaccumulation and biotransformation of brominated flame retardants, and specifically polybrominated diphenyl ethers,(PBDEs). Her current research projects explore the routes of human exposure to flame retardant chemicals and examine the way these compounds are photodegraded and metabolized using mass spectrometry to identify breakdown products/metabolites. She uses both in vivo techniques iwth fish, and in vitro techniques with cell cultures to examine metabolism of this varied class of chemicals. Also of interest to Dr. Stapleton is the study of the fate of PBDEs in the environment which may lead to bioaccumulation in aquatic systems and examining their bioavailability under different environmental conditions.

Appointments and Affiliations

  • Dan and Bunny Gabel Associate Professor of Environmental Ethics and Sustainable Environmental Management
  • Associate Professor of Environmental Sciences and Policy in the Nicholas School of the Environment
  • Associate Professor in the Department of Civil and Environmental Engineering
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: 450 Research Drive, LSRC Room A220, Durham, NC 27519
  • Office Phone: (919) 613-8717
  • Email Address: heather.stapleton@duke.edu


  • Ph.D. University of Maryland, College Park, 2003
  • M.S. University of Maryland, College Park, 2000
  • B.S. Long Island University Southhampton College, 1997


environmental chemistry
environmental health
environmental toxicology

Courses Taught

  • CEE 563: Chemical Fate of Organic Compounds
  • ENVIRON 360: Environmental Chemistry and Toxicology
  • ENVIRON 393: Research Independent Study
  • ENVIRON 394: Research Independent Study
  • ENVIRON 540: Chemical Fate of Organic Compounds
  • ENVIRON 593: Independent Studies and Projects
  • ENVIRON 780: Environmental Exposure Analysis
  • ENVIRON 898: Program Area Seminar
  • ENVIRON 899: Master's Project

In the News

Representative Publications

  • Castorina, R; Bradman, A; Stapleton, HM; Butt, C; Avery, D; Harley, KG; Gunier, RB; Holland, N; Eskenazi, B, Current-use flame retardants: Maternal exposure and neurodevelopment in children of the CHAMACOS cohort., Chemosphere, vol 189 (2017), pp. 574-580 [10.1016/j.chemosphere.2017.09.037] [abs].
  • Luz, AL; Kassotis, CD; Stapleton, HM; Meyer, JN, The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARγ activation, in 3T3-L1 cells., TOXICOLOGY, vol 393 (2017), pp. 150-159 [10.1016/j.tox.2017.11.010] [abs].
  • Phillips, AL; Hammel, SC; Konstantinov, A; Stapleton, HM, Characterization of Individual Isopropylated and tert-Butylated Triarylphosphate (ITP and TBPP) Isomers in Several Commercial Flame Retardant Mixtures and House Dust Standard Reference Material SRM 2585., Environmental Science & Technology, vol 51 no. 22 (2017), pp. 13443-13449 [10.1021/acs.est.7b04179] [abs].
  • Siebenaler, R; Cameron, R; Butt, CM; Hoffman, K; Higgins, CP; Stapleton, HM, Serum perfluoroalkyl acids (PFAAs) and associations with behavioral attributes., Chemosphere, vol 184 (2017), pp. 687-693 [10.1016/j.chemosphere.2017.06.023] [abs].
  • Hammel, SC; Hoffman, K; Lorenzo, AM; Chen, A; Phillips, AL; Butt, CM; Sosa, JA; Webster, TF; Stapleton, HM, Associations between flame retardant applications in furniture foam, house dust levels, and residents' serum levels., Environment International, vol 107 (2017), pp. 181-189 [10.1016/j.envint.2017.07.015] [abs].

Additional Information