Heather M. Stapleton

Heather M. Stapleton

Dan and Bunny Gabel Associate Professor of Environmental Ethics and Sustainable Environmental Management

Dr. Stapleton's research focuses on understanding the fate and transformation of organic contaminants in aquatic systems and in indoor environments. Her main focus has been on the bioaccumulation and biotransformation of brominated flame retardants, and specifically polybrominated diphenyl ethers,(PBDEs). Her current research projects explore the routes of human exposure to flame retardant chemicals and examine the way these compounds are photodegraded and metabolized using mass spectrometry to identify breakdown products/metabolites. She uses both in vivo techniques iwth fish, and in vitro techniques with cell cultures to examine metabolism of this varied class of chemicals. Also of interest to Dr. Stapleton is the study of the fate of PBDEs in the environment which may lead to bioaccumulation in aquatic systems and examining their bioavailability under different environmental conditions.

Appointments and Affiliations

  • Dan and Bunny Gabel Associate Professor of Environmental Ethics and Sustainable Environmental Management
  • Associate Professor of Environmental Sciences and Policy in the Nicholas School of the Environment
  • Associate Professor in the Department of Civil and Environmental Engineering
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: 450 Research Drive, LSRC Room A220, Durham, NC 27519
  • Office Phone: (919) 613-8717
  • Email Address: heather.stapleton@duke.edu


  • Ph.D. University of Maryland, College Park, 2003
  • M.S. University of Maryland, College Park, 2000
  • B.S. Long Island University Southhampton College, 1997


environmental chemistry
environmental health
environmental toxicology

Courses Taught

  • CEE 563: Chemical Fate of Organic Compounds
  • ENVIRON 360: Environmental Chemistry and Toxicology
  • ENVIRON 393: Research Independent Study
  • ENVIRON 394: Research Independent Study
  • ENVIRON 540: Chemical Fate of Organic Compounds
  • ENVIRON 593: Independent Studies and Projects
  • ENVIRON 780: Environmental Exposure Analysis
  • ENVIRON 898: Program Area Seminar
  • ENVIRON 899: Master's Project

In the News

Representative Publications

  • Macaulay, LJ; Chernick, M; Chen, A; Hinton, DE; Bailey, JM; Kullman, SW; Levin, ED; Stapleton, HM, Exposure to a PBDE/OH-BDE mixture alters juvenile zebrafish (Danio rerio) development., Environmental Toxicology & Chemistry, vol 36 no. 1 (2017), pp. 36-48 [10.1002/etc.3535] [abs].
  • Leonetti, C; Butt, CM; Hoffman, K; Hammel, SC; Miranda, ML; Stapleton, HM, Brominated flame retardants in placental tissues: associations with infant sex and thyroid hormone endpoints., Environmental Health, vol 15 no. 1 (2016) [10.1186/s12940-016-0199-8] [abs].
  • Phillips, AL; Chen, A; Rock, KD; Horman, B; Patisaul, HB; Stapleton, HM, Editor's Highlight: Transplacental and Lactational Transfer of Firemaster® 550 Components in Dosed Wistar Rats., Toxicological Sciences (Elsevier), vol 153 no. 2 (2016), pp. 246-257 [10.1093/toxsci/kfw122] [abs].
  • Cooper, EM; Kroeger, G; Davis, K; Clark, CR; Ferguson, PL; Stapleton, HM, Results from Screening Polyurethane Foam Based Consumer Products for Flame Retardant Chemicals: Assessing Impacts on the Change in the Furniture Flammability Standards., Environmental Science & Technology, vol 50 no. 19 (2016), pp. 10653-10660 [10.1021/acs.est.6b01602] [abs].
  • Butt, CM; Hoffman, K; Chen, A; Lorenzo, A; Congleton, J; Stapleton, HM, Regional comparison of organophosphate flame retardant (PFR) urinary metabolites and tetrabromobenzoic acid (TBBA) in mother-toddler pairs from California and New Jersey., Environment International, vol 94 (2016), pp. 627-634 [10.1016/j.envint.2016.06.029] [abs].

Additional Information