Richard T Di Giulio
Professor of Environmental ToxicologyDr. Di Giulio serves as Director of Duke University's Integrated Toxicology Program and the Superfund Basic Research Center. Dr. Di Giulio's research is concerned with basic studies of mechanisms of contaminant metabolism, adaptation and toxicity, and with the development of mechanistically-based indices of exposure and toxicity that can be employed in biomonitoring. The long term goals of this research are to bridge the gap between mechanistic toxicological research and the development of useful tools for environmental assessment, and to elucidate linkages between human and ecosystem health. The bulk of Dr. Di Giulio's work employs a comparative approach with aquatic animals, particularly fishes, as models. Of particular concern are mechanisms of oxidative metabolism of aromatic hydrocarbons, mechanisms of free radical production and antioxidant defense, and mechanisms of chemical carcinogenesis, developmental perturbations and adaptations to contaminated environments by fishes.
Appointments and Affiliations
- Professor of Environmental Toxicology
- Professor in the Department of Civil and Environmental Engineering
- Interim Chair of the Environmental Sciences and Policy Division
- Office Location: A346B Lev Sci Res Ctr, Durham, NC 27708
- Office Phone: (919) 613-8024
- Email Address: email@example.com
- Ph.D. Virginia Polytech Institute and State University, 1982
- M.S. Louisiana State University at Baton Rouge, 1978
- B.A. University of Texas at Austin, 1972
- ENVIRON 360: Environmental Chemistry and Toxicology
- ENVIRON 393: Research Independent Study
- ENVIRON 394: Research Independent Study
- ENVIRON 501: Environmental Toxicology
- ENVIRON 537: Environmental Health
- ENVIRON 593: Independent Studies and Projects
- ENVIRON 899: Master's Project
- ENVIRON 997: Duke Environmental Leadership: Independent Studies and Projects
- ENVIRON 999: Duke Environmental Leadership: Master's Project
In the News
- Synthetic Chemicals Understudied Drivers of Environmental Change (Jan 24, 2017 | Nicholas School of the Environment )
- Blocking Key Gene Reduces Cigarette Smoke Toxicity in Fish Embryos (Sep 19, 2016)
- Duke Awards Distinguished Professorships, Inducts New Bass Society Members (May 5, 2016)
- An Unexpected Direction (Nov 10, 2014)
- Duke And UNC Superfund Research Centers Hosting Visiting Journalists (Mar 10, 2014)
- Mining Appalachia has permanent effects on its landscape (Jan 28, 2014 | Duke Research Blog )
- Brown, DR; Clark, BW; Garner, LV; Di Giulio, RT, Embryonic cardiotoxicity of weak aryl hydrocarbon receptor agonists and CYP1A inhibitor fluoranthene in the Atlantic killifish (Fundulus heteroclitus)., Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology, vol 188 (2016), pp. 45-51 [10.1016/j.cbpc.2016.05.005] [abs].
- Matson, CW; Bone, AJ; Auffan, M; Lindberg, TT; Arnold, MC; Hsu-Kim, H; Wiesner, MR; Di Giulio, RT, Silver toxicity across salinity gradients: the role of dissolved silver chloride species (AgCl x ) in Atlantic killifish (Fundulus heteroclitus) and medaka (Oryzias latipes) early life-stage toxicity., Ecotoxicology, vol 25 no. 6 (2016), pp. 1105-1118 [10.1007/s10646-016-1665-3] [abs].
- Riley, AK; Chernick, M; Brown, DR; Hinton, DE; Di Giulio, RT, Hepatic Responses of Juvenile Fundulus heteroclitus from Pollution-adapted and Nonadapted Populations Exposed to Elizabeth River Sediment Extract., Toxicologic Pathology (Sage), vol 44 no. 5 (2016), pp. 738-748 [10.1177/0192623316636717] [abs].
- Arnold, MC; Forte, JE; Osterberg, JS; Di Giulio, RT, Antioxidant Rescue of Selenomethionine-Induced Teratogenesis in Zebrafish Embryos., Archives of Environmental Contamination and Toxicology, vol 70 no. 2 (2016), pp. 311-320 [10.1007/s00244-015-0235-7] [abs].
- Brown, DR; Bailey, JM; Oliveri, AN; Levin, ED; Di Giulio, RT, Developmental exposure to a complex PAH mixture causes persistent behavioral effects in naive Fundulus heteroclitus (killifish) but not in a population of PAH-adapted killifish., Neurotoxicology and Teratology, vol 53 (2016), pp. 55-63 [10.1016/j.ntt.2015.10.007] [abs].