Heather M. Stapleton

Stapleton

Dan and Bunny Gabel Associate Professor of Environmental Ethics and Sustainable Environmental Management

Dr. Stapleton's research focuses on understanding the fate and transformation of organic contaminants in aquatic systems and in indoor environments. Her main focus has been on the bioaccumulation and biotransformation of brominated flame retardants, and specifically polybrominated diphenyl ethers,(PBDEs). Her current research projects explore the routes of human exposure to flame retardant chemicals and examine the way these compounds are photodegraded and metabolized using mass spectrometry to identify breakdown products/metabolites. She uses both in vivo techniques iwth fish, and in vitro techniques with cell cultures to examine metabolism of this varied class of chemicals. Also of interest to Dr. Stapleton is the study of the fate of PBDEs in the environment which may lead to bioaccumulation in aquatic systems and examining their bioavailability under different environmental conditions.

Appointments and Affiliations

  • Dan and Bunny Gabel Associate Professor of Environmental Ethics and Sustainable Environmental Management
  • Associate Professor of Environmental Sciences and Policy in the Nicholas School of the Environment
  • Associate Professor in the Department of Civil and Environmental Engineering
  • Associate Professor in Pediatrics
  • Member of the Duke Cancer Institute

Contact Information

  • Office Location: 9 Circuit Drive, Box 90328, LSRC Room A207, Durham, NC 27710
  • Office Phone: (919) 613-8717
  • Email Address: heather.stapleton@duke.edu

Education

  • Ph.D. University of Maryland, College Park, 2003
  • M.S. University of Maryland, College Park, 2000
  • B.S. Long Island University Southhampton College, 1997

Awards, Honors, and Distinctions

  • Highly Cited Researcher. Thomson Reuters. 2014

Courses Taught

  • CEE 563: Chemical Fate of Organic Compounds
  • ENVIRON 360: Environmental Chemistry and Toxicology
  • ENVIRON 393: Research Independent Study
  • ENVIRON 394: Research Independent Study
  • ENVIRON 540: Chemical Fate of Organic Compounds
  • ENVIRON 593: Independent Studies and Projects
  • ENVIRON 780: Environmental Exposure Analysis
  • ENVIRON 898: Program Area Seminar
  • ENVIRON 899: Master's Project

In the News

Representative Publications

  • Bastiaensen, M; Van den Eede, N; Su, G; Letcher, RJ; Stapleton, HM; Covaci, A, Towards establishing indicative values for metabolites of organophosphate ester contaminants in human urine., Chemosphere, vol 236 (2019) [10.1016/j.chemosphere.2019.124348] [abs].
  • Phillips, AL; Stapleton, HM, Inhibition of Human Liver Carboxylesterase (hCE1) by Organophosphate Ester Flame Retardants and Plasticizers: Implications for Pharmacotherapy., Toxicological Sciences (2019) [10.1093/toxsci/kfz149] [abs].
  • Doherty, BT; Hoffman, K; Keil, AP; Engel, SM; Stapleton, HM; Goldman, BD; Olshan, AF; Daniels, JL, Prenatal exposure to organophosphate esters and behavioral development in young children in the Pregnancy, Infection, and Nutrition Study., Neurotoxicology, vol 73 (2019), pp. 150-160 [10.1016/j.neuro.2019.03.007] [abs].
  • Dembsey, NA; Brokaw, FM; Stapleton, HM; Dodson, RE; Onasch, J; Jazan, E; Carignan, CC, Intervention to reduce gymnast exposure to flame retardants from pit foam: A case study., Environment International, vol 127 (2019), pp. 868-875 [10.1016/j.envint.2019.01.084] [abs].
  • Kassotis, CD; Kollitz, EM; Hoffman, K; Sosa, JA; Stapleton, HM, Thyroid receptor antagonism as a contributory mechanism for adipogenesis induced by environmental mixtures in 3T3-L1 cells., The Science of the Total Environment, vol 666 (2019), pp. 431-444 [10.1016/j.scitotenv.2019.02.273] [abs].