Joel Meyer

Bio

Dr. Meyer studies the effects of toxic agents and stressors on human and wildlife health. He is particularly interested in understanding the mechanisms by which environmental agents cause DNA damage, the molecular processes that organisms employ to protect prevent and repair DNA damage, and genetic differences that may lead to increased or decreased sensitivity to DNA damage. Mitochondrial DNA damage and repair, as well as mitochondrial function in general, are a particular focus. He studies these effects in the nematode Caenorhabditis elegans, in cell culture, and collaboratively in other laboratory model organisms as well as in human populations in the USA and globally.

Education

• B.S. Juniata College, 1992
• Ph.D. Duke University, 2003

Positions

• Sally Kleberg Distinguished Professorship
• Professor of Environmental Genomics in the Division of Environmental Sciences and Policy
• Professor in the Department of Civil and Environmental Engineering
• Affiliate, Duke Global Health Institute
• Member of the Duke Cancer Institute

Courses Taught

• PHARM 848S: Seminar in Toxicology
• PHARM 847S: Seminar in Toxicology
• ENVIRON 899: Master's Project
• ENVIRON 898: Program Area Seminar
• ENVIRON 848S: Seminar in Toxicology
• ENVIRON 847S: Seminar in Toxicology
• ENVIRON 819: Mechanisms in Environmental Toxicology
• ENVIRON 501: Environmental Toxicology
• ENVIRON 394: Research Independent Study
• ENVIRON 393: Research Independent Study

Publications

• King DE, Beard EE, Satusky MJ, Ryde IT, George A, Johnson C, et al. TFAM as a sensor of UVC-induced mitochondrial DNA damage. bioRxiv. 2024 Nov 1;
• Carrothers S, Trevisan R, Jayasundara N, Pelletier N, Weeks E, Meyer JN, et al. An epigenetic memory at the CYP1A gene in cancer-resistant, pollution-adapted killifish. bioRxiv. 2024 Aug 16;
• Mello DF, Perez L, Bergemann CM, Morton KS, Ryde IT, Meyer JN. Comprehensive characterization of mitochondrial bioenergetics at different larval stages reveals novel insights about the developmental metabolism of Caenorhabditis elegans. bioRxiv. 2024 Jun 30;
• King DE, Sparling AC, Joyce AS, Ryde IT, DeSouza B, Ferguson PL, et al. Lack of detectable sex differences in the mitochondrial function of Caenorhabditis elegans. BMC Ecol Evol. 2024 Apr 26;24(1):55.
• Meyer JN, Pan WK, Ryde IT, Alexander T, Klein-Adams JC, Ndirangu DS, et al. Correction: Bioenergetic function is decreased in peripheral blood mononuclear cells of veterans with Gulf War Illness. PloS one. 2024 Jan;19(4):e0302501.
• King DE, Lalwani PD, Mercado GP, Dolan EL, Frierson JM, Meyer JN, et al. The use of race terms in epigenetics research: considerations moving forward. Front Genet. 2024;15:1348855.
• Carrothers S, Jayasundara N, Trevisan R, Rice S, Pelletier N, Weeks E, et al. Reversible epigenetic adaptation to polycyclic aromatic hydrocarbons at the CYP1A gene in Fundulus heteroclitus. In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2024. p. 47–47.
• Timme-Laragy AR, Di Giulio RT, Meyer JN. Reactive Oxygen Species and Redox Stress. In: Toxicology of Fishes. 2024. p. 121–55.
• Morton KS, Wahl AK, Meyer JN. The effect of common paralytic agents used for fluorescence imaging on redox tone and ATP levels in Caenorhabditis elegans. PloS one. 2024 Jan;19(4):e0292415.
• Clark AS, Huayta J, Morton KS, Meyer JN, San-Miguel A. Morphological hallmarks of dopaminergic neurodegeneration are associated with altered neuron function in Caenorhabditis elegans. Neurotoxicology. 2024 Jan;100:100–6.
• Mello DF, Perez L, Bergemann CM, Morton KS, Ryde IT, Meyer JN. Comprehensive characterization of mitochondrial bioenergetics at different larval stages reveals novel insights about the developmental metabolism of Caenorhabditis elegans. PloS one. 2024 Jan;19(11):e0306849.
• Lalwani P, King DE, Morton KS, Rivera NA, Huayta J, Hsu-Kim H, et al. Increased cytotoxicity of Pb²⁺ with co-exposures to a mitochondrial uncoupler and mitochondrial calcium uniporter inhibitor. Environmental science Processes & impacts. 2023 Nov;25(11):1743–51.
• Morton KS, Hartman JH, Heffernan N, Ryde IT, Kenny-Ganzert IW, Meng L, et al. Chronic high-sugar diet in adulthood protects Caenorhabditis elegans from 6-OHDA-induced dopaminergic neurodegeneration. BMC biology. 2023 Nov;21(1):252.
• Kozal JS, Jayasundara N, Massarsky A, Lindberg CD, Oliveri AN, Cooper EM, et al. Mitochondrial dysfunction and oxidative stress contribute to cross-generational toxicity of benzo(a)pyrene in Danio rerio. Aquatic toxicology (Amsterdam, Netherlands). 2023 Oct;263:106658.
• Morton KS, Wahl AK, Meyer JN. The effect of common paralytic agents used for fluorescence imaging on redox tone and ATP levels in Caenorhabditis elegans. bioRxiv. 2023 Sep 23;
• Clark AS, Huayta J, Morton KS, Meyer JN, San-Miguel A. Morphological hallmarks of dopaminergic neurodegeneration are associated with altered neuron function in Caenorhabditis elegans. bioRxiv. 2023 Aug 23;
• Clark AS, Kalmanson Z, Morton K, Hartman J, Meyer J, San-Miguel A. An unbiased, automated platform for scoring dopaminergic neurodegeneration in C. elegans. PloS one. 2023 Jan;18(7):e0281797.
• Huayta J, Meyer JN. Effects of Exposure to Environmental Pollutants Causing Mitochondrial DNA Damage and Depletion on C. elegans Healthspan. In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2023. p. 11–2.
• Morton K, Hartman J, Heffernan N, Ryde I, Kenny-Ganzert I, Meng L, et al. Chronic high-sugar diet in adulthood protectsCaenorhabditis elegansfrom 6-OHDA induced dopaminergic neurodegeneration. bioRxiv. 2023.
• Meyer JN, Pan WK, Ryde IT, Alexander T, Klein-Adams JC, Ndirangu DS, et al. Bioenergetic function is decreased in peripheral blood mononuclear cells of veterans with Gulf War Illness. PloS one. 2023 Jan;18(11):e0287412.
• Sparling AC, King DE, Meyer JN. rol-6 and dpy-10C. elegans mutants have normal mitochondrial function after normalizing to delayed development. microPublication biology. 2023 Jan;2023.
• King DE, Sparling AC, Lloyd D, Satusky MJ, Martinez M, Grenier C, et al. Sex-specific DNA methylation and associations with in utero tobacco smoke exposure at nuclear-encoded mitochondrial genes. Epigenetics. 2022 Dec;17(12):1573–89.
• Leuthner TC, Benzing L, Kohrn BF, Bergemann CM, Hipp MJ, Hershberger KA, et al. Resistance of mitochondrial DNA to cadmium and Aflatoxin B1 damage-induced germline mutation accumulation in C. elegans. Nucleic Acids Res. 2022 Aug 26;50(15):8626–42.
• Berky AJ, Robie E, Navio Chipa S, Ortiz EJ, Palmer EJ, Rivera NA, et al. Risk of lead exposure from wild game consumption from cross-sectional studies in Madre de Dios, Peru. Lancet regional health Americas. 2022 Aug;12:100266.
• Maglioni S, Schiavi A, Melcher M, Brinkmann V, Luo Z, Laromaine A, et al. Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans. Nature communications. 2022 May;13(1):2620.
• Joglekar R, Cauley M, Lipsich T, Corcoran DL, Patisaul HB, Levin ED, et al. Developmental nicotine exposure and masculinization of the rat preoptic area. Neurotoxicology. 2022 Mar;89:41–54.
• Maeso-Díaz R, Dalton GD, Oh S, Du K, Tang L, Chen T, et al. Aging reduces liver resiliency by dysregulating Hedgehog signaling. In: Aging Cell. 2022. p. e13530.
• Mello DF, Bergemann CM, Fisher K, Chitrakar R, Bijwadia SR, Wang Y, et al. Rotenone Modulates Caenorhabditis elegans Immunometabolism and Pathogen Susceptibility. Frontiers in immunology. 2022 Jan;13:840272.
• Maglioni S, Schiavi A, Melcher M, Brinkmann V, Luo Z, Laromaine A, et al. Lutein rescues a nlg-1-mediated synaptic defect in a C. elegans mitochondrial complex I deficiency model. In: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2022. p. S59–S59.
• Markovich ZR, Hartman JH, Ryde IT, Hershberger KA, Joyce AS, Ferguson PL, et al. Mild pentachlorophenol-mediated uncoupling of mitochondria depletes ATP but does not cause an oxidized redox state or dopaminergic neurodegeneration in Caenorhabditis elegans. Current research in toxicology. 2022 Jan;3:100084.
• Mello DF, Maurer LL, Ryde IT, Songr DH, Marinakos SM, Jiang C, et al. In Vivo Effects of Silver Nanoparticles on Development, Behavior, and Mitochondrial Function are Altered by Genetic Defects in Mitochondrial Dynamics. Environmental science & technology. 2022 Jan;56(2):1113–24.
• Leuthner TC, Meyer JN. Mitochondrial DNA Mutagenesis: Feature of and Biomarker for Environmental Exposures and Aging. Current environmental health reports. 2021 Dec;8(4):294–308.
• Bijwadia SR, Morton K, Meyer JN. Quantifying Levels of Dopaminergic Neuron Morphological Alteration and Degeneration in Caenorhabditis elegans. Journal of visualized experiments : JoVE. 2021 Nov;(177).
• Wang L, Mello DF, Zucker RM, Rivera NA, Rogers NMK, Geitner NK, et al. Lack of Detectable Direct Effects of Silver and Silver Nanoparticles on Mitochondria in Mouse Hepatocytes. Environmental science & technology. 2021 Aug;55(16):11166–75.
• Hershberger KA, Rooney JP, Turner EA, Donoghue LJ, Bodhicharla R, Maurer LL, et al. Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans. Redox Biol. 2021 Jul;43:102000.
• Hartman JH, Widmayer SJ, Bergemann CM, King DE, Morton KS, Romersi RF, et al. Xenobiotic metabolism and transport in Caenorhabditis elegans. Journal of toxicology and environmental health Part B, Critical reviews. 2021 Feb;24(2):51–94.
• Gonzalez-Hunt CP, Luz AL, Ryde IT, Turner EA, Ilkayeva OR, Bhatt DP, et al. Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone. Toxicology. 2021 Jan 15;447:152630.
• King DE, Sparling AC, Joglekar R, Meyer JN, Murphy SK. Direct comparisons of bisulfite pyrosequencing versus targeted bisulfite sequencing. MicroPubl Biol. 2021;2021.
• Leuthner TC, Hartman JH, Ryde IT, Meyer JN. PCR-Based Determination of Mitochondrial DNA Copy Number in Multiple Species. Methods in molecular biology (Clifton, NJ). 2021 Jan;2310:91–111.
• Huang W, Liu Y, Luz A, Berrong M, Meyer JN, Zou Y, et al. Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-Induced Myeloid-Derived Suppressor Cells. Front Immunol. 2021;12:754083.
• Yang P, Shao Z, Besley NA, Neal SE, Buehne KL, Park J, et al. Risuteganib Protects against Hydroquinone-induced Injury in Human RPE Cells. Invest Ophthalmol Vis Sci. 2020 Aug 3;61(10):35.
• Berky AJ, Robie E, Ortiz EJ, Meyer JN, Hsu-Kim H, Pan WK. Evaluation of Peruvian Government Interventions to Reduce Childhood Anemia. Annals of global health. 2020 Aug;86(1):98.
• Harris JB, Hartman JH, Luz AL, Wilson JY, Dinyari A, Meyer JN. Zebrafish CYP1A expression in transgenic Caenorhabditis elegans protects from exposures to benzo[a]pyrene and a complex polycyclic aromatic hydrocarbon mixture. Toxicology. 2020 Jul;440:152473.
• Zhang J, Hartman JH, Chen C, Yang S, Li Q, Tian Z, et al. Fluorescence-based sorting of Caenorhabditis elegans via acoustofluidics. Lab on a chip. 2020 May;20(10):1729–39.
• Nash A, Samoylova M, Leuthner T, Zhu M, Lin L, Meyer JN, et al. Effects of Immunosuppressive Medications on Mitochondrial Function. The Journal of surgical research. 2020 May;249:50–7.
• Neal SE, Buehne KL, Besley NA, Yang P, Silinski P, Hong J, et al. Resveratrol Protects Against Hydroquinone-Induced Oxidative Threat in Retinal Pigment Epithelial Cells. Invest Ophthalmol Vis Sci. 2020 Apr 9;61(4):32.
• King D, Martinez M, Lloyd D, Maguire R, Hoyo C, Meyer JN, et al. Analysis of Illumina 450K DNA Methylation in NEST Cord Blood Reveals Sex Differences at Mitochondrial Genes in the Nuclear Genome. In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2020. p. 34–5.
• Mello DF, Trevisan R, Rivera N, Geitner NK, Di Giulio RT, Wiesner MR, et al. Caveats to the use of MTT, neutral red, Hoechst and Resazurin to measure silver nanoparticle cytotoxicity. Chemico-biological interactions. 2020 Jan;315:108868.
• Alexander T, Falvo MJ, Ryde I, Klein-Adams J, Ndirangu DS, Watson M, et al. Characterizing The Bioenergetic Profile Of White Blood Cells For Utility In Assessing Mitochondrial Dysfunction In Gulf War Illness. In: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020. p. 302–302.
• Hartman JH, Richie CT, Gordon KL, Mello DF, Castillo P, Zhu A, et al. MANF deletion abrogates early larval Caenorhabditis elegans stress response to tunicamycin and Pseudomonas aeruginosa. European journal of cell biology. 2019 Dec;98(5–8):151043.
• Laranjeiro R, Harinath G, Hewitt JE, Hartman JH, Royal MA, Meyer JN, et al. Swim exercise in Caenorhabditis elegans extends neuromuscular and gut healthspan, enhances learning ability, and protects against neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 2019 Nov;116(47):23829–39.
• Leung MCK, Meyer JN. Mitochondria as a target of organophosphate and carbamate pesticides: Revisiting common mechanisms of action with new approach methodologies. Reproductive toxicology (Elmsford, NY). 2019 Oct;89:83–92.
• Smith LL, Ryde IT, Hartman JH, Romersi RF, Markovich Z, Meyer JN. Strengths and limitations of morphological and behavioral analyses in detecting dopaminergic deficiency in Caenorhabditis elegans. Neurotoxicology. 2019 Sep;74:209–20.
• Leuthner TC, Keith RN, Jackson C, Glaholt SP, Meyer JN, Shaw JR. Variation in Signatures of Cadmium-induced Mitochondrial DNA Mutations Reveal Evolutionary Effects of Pollution. In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. WILEY; 2019. p. 81–81.
• Leuthner TC, Kennedy SR, Meyer JN. Ultra-sensitive Duplex Sequencing Reveals Influence of Exogenous Stressors on Mitochondrial DNA Mutagenesis. In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. WILEY; 2019. p. 53–4.
• Dreier DA, Mello DF, Meyer JN, Martyniuk CJ. Linking Mitochondrial Dysfunction to Organismal and Population Health in the Context of Environmental Pollutants: Progress and Considerations for Mitochondrial Adverse Outcome Pathways. Environmental toxicology and chemistry. 2019 Aug;38(8):1625–34.
• Maglioni S, Mello DF, Schiavi A, Meyer JN, Ventura N. Mitochondrial bioenergetic changes during development as an indicator of C. elegans health-span. Aging. 2019 Aug;11(16):6535–54.
• Bachman H, Fu H, Huang P-H, Tian Z, Embry-Seckler J, Rufo J, et al. Open source acoustofluidics. Lab on a chip. 2019 Jul;19(14):2404–14.
• Hartman JH, Gonzalez-Hunt C, Hall SM, Ryde IT, Caldwell KA, Caldwell GA, et al. Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration. International journal of molecular sciences. 2019 Jun;20(13):E3202.
• Zhang J, Yang S, Chen C, Hartman JH, Huang P-H, Wang L, et al. Surface acoustic waves enable rotational manipulation of Caenorhabditis elegans. Lab on a chip. 2019 Mar;19(6):984–92.
• Berky AJ, Ryde IT, Feingold B, Ortiz EJ, Wyatt LH, Weinhouse C, et al. Predictors of mitochondrial DNA copy number and damage in a mercury-exposed rural Peruvian population near artisanal and small-scale gold mining: An exploratory study. Environmental and molecular mutagenesis. 2019 Mar;60(2):197–210.
• Cothren SD, Meyer JN, Hartman JH. Blinded Visual Scoring of Images Using the Freely-available Software Blinder. Bio-protocol. 2018 Dec;8(23):e3103.
• Hibshman JD, Leuthner TC, Shoben C, Mello DF, Sherwood DR, Meyer JN, et al. Nonselective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans. American journal of physiology Cell physiology. 2018 Dec;315(6):C781–92.
• Weinhouse C, Truong L, Meyer JN, Allard P. Caenorhabditis elegans as an emerging model system in environmental epigenetics. Environmental and molecular mutagenesis. 2018 Aug;59(7):560–75.
• Sanders LH, Rouanet JP, Howlett EH, Leuthner TC, Rooney JP, Greenamyre JT, et al. Newly Revised Quantitative PCR-Based Assay for Mitochondrial and Nuclear DNA Damage. Curr Protoc Toxicol. 2018 May;76(1):e50.
• Hartman JH, Smith LL, Gordon KL, Laranjeiro R, Driscoll M, Sherwood DR, et al. Swimming Exercise and Transient Food Deprivation in Caenorhabditis elegans Promote Mitochondrial Maintenance and Protect Against Chemical-Induced Mitotoxicity. Scientific reports. 2018 May;8(1):8359.
• Meyer JN, Hartman JH, Mello DF. Mitochondrial Toxicity. Toxicological sciences : an official journal of the Society of Toxicology. 2018 Mar;162(1):15–23.
• Maurer LL, Luz AL, Meyer JN. Detection of Mitochondrial Toxicity of Environmental Pollutants Using Caenorhabditis elegans. In: Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. 2018. p. 655–89.
• Luz AL, Kassotis CD, Stapleton HM, Meyer JN. The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARγ activation, in 3T3-L1 cells. Toxicology. 2018 Jan;393:150–9.
• Hartman JH, Gordon KL, Sherwood DR, Meyer JN. Humanized, transgenic worms to study the role of mitochondrial CYP2E1 in toxicant-induced mitochondrial dysfunction and neurodegeneration. In: Drug Metabolism and Pharmacokinetics. Elsevier BV; 2018. p. S35–S35.
• Meyer JN, Leuthner TC, Luz AL. Mitochondrial fusion, fission, and mitochondrial toxicity. Toxicology. 2017 Nov;391:42–53.
• Meyer JN, Chan SSL. Sources, mechanisms, and consequences of chemical-induced mitochondrial toxicity. Toxicology. 2017 Nov;391:2–4.
• Leuthner T, Keith NR, Jackson C, Meyer JN, Shaw JR. Adaptation to cadmium reveals mechanism and susceptibility to mitochondrial genotoxicity. In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. WILEY; 2017. p. S46–S46.
• Gonzalez-Moragas L, Maurer LL, Harms VM, Meyer JN, Laromaine A, Roig A. Materials and toxicological approaches to study metal and metal-oxide nanoparticles in the model organism Caenorhabditis elegans. Materials horizons. 2017 Sep;4(5):719–46.
• Hartman JH, Kozal JS, Di Giulio RT, Meyer JN. Zebrafish have an ethanol-inducible hepatic 4-nitrophenol hydroxylase that is not CYP2E1-like. Environmental toxicology and pharmacology. 2017 Sep;54:142–5.
• Luz AL, Godebo TR, Smith LL, Leuthner TC, Maurer LL, Meyer JN. Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability. Toxicology. 2017 Jul;387:81–94.
• Weinstein JR, Asteria-Peñaloza R, Diaz-Artiga A, Davila G, Hammond SK, Ryde IT, et al. Exposure to polycyclic aromatic hydrocarbons and volatile organic compounds among recently pregnant rural Guatemalan women cooking and heating with solid fuels. International journal of hygiene and environmental health. 2017 Jun;220(4):726–35.
• Wyatt LH, Luz AL, Cao X, Maurer LL, Blawas AM, Aballay A, et al. Effects of methyl and inorganic mercury exposure on genome homeostasis and mitochondrial function in Caenorhabditis elegans. DNA repair. 2017 Apr;52:31–48.
• Lewis JJ, Hollingsworth JW, Chartier RT, Cooper EM, Foster WM, Gomes GL, et al. Biogas Stoves Reduce Firewood Use, Household Air Pollution, and Hospital Visits in Odisha, India. Environ Sci Technol. 2017 Jan 3;51(1):560–9.
• Chen Y, Meyer JN, Hill HZ, Lange G, Condon MR, Klein JC, et al. Correction: Role of mitochondrial DNA damage and dysfunction in veterans with Gulf War Illness. PloS one. 2017 Jan;12(10):e0186711.
• Chen Y, Meyer JN, Hill HZ, Lange G, Condon MR, Klein JC, et al. Role of mitochondrial DNA damage and dysfunction in veterans with Gulf War Illness. PloS one. 2017 Jan;12(9):e0184832.
• Hartman JH, Miller GP, Meyer JN. Toxicological Implications of Mitochondrial Localization of CYP2E1. Toxicology research. 2017 Jan;6(3):273–89.
• Luz AT, Godebo TR, Bhatt DP, Ilkayeva OR, Maurer LL, Hirschey MD, et al. Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-Like Effect in Caenorhabditis elegans. Toxicol Sci. 2016 Nov;154(1):195.
• Santa-Gonzalez GA, Gomez-Molina A, Arcos-Burgos M, Meyer JN, Camargo M. Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest. Redox biology. 2016 Oct;9:124–33.
• Luz AL, Meyer JN. Effects of reduced mitochondrial DNA content on secondary mitochondrial toxicant exposure in Caenorhabditis elegans. Mitochondrion. 2016 Sep;30:255–64.
• Maurer LL, Yang X, Schindler AJ, Taggart RK, Jiang C, Hsu-Kim H, et al. Intracellular trafficking pathways in silver nanoparticle uptake and toxicity in Caenorhabditis elegans. Nanotoxicology. 2016 Sep;10(7):831–5.
• Luz AL, Lagido C, Hirschey MD, Meyer JN. In Vivo Determination of Mitochondrial Function Using Luciferase-Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant-Induced Dysfunction. Curr Protoc Toxicol. 2016 Aug 1;69:25.8.1-25.8.22.
• Luz AL, Godebo TR, Bhatt DP, Ilkayeva OR, Maurer LL, Hirschey MD, et al. From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans. Toxicol Sci. 2016 Aug;152(2):349–62.
• Maurer LL, Meyer JN. A systematic review of evidence for silver nanoparticle-induced mitochondrial toxicity. Environmental Science: Nano. 2016 Apr 1;3(2):311–22.
• Wyatt LH, Diringer SE, Rogers LA, Hsu-Kim H, Pan WK, Meyer JN. Antagonistic Growth Effects of Mercury and Selenium in Caenorhabditis elegans Are Chemical-Species-Dependent and Do Not Depend on Internal Hg/Se Ratios. Environmental science & technology. 2016 Mar;50(6):3256–64.
• Gonzalez-Hunt CP, Rooney JP, Ryde IT, Anbalagan C, Joglekar R, Meyer JN. PCR-Based Analysis of Mitochondrial DNA Copy Number, Mitochondrial DNA Damage, and Nuclear DNA Damage. Current protocols in toxicology. 2016 Feb;67:20.11.1-20.11.25.
• Van Houten B, Hunter SE, Meyer JN. Mitochondrial DNA damage induced autophagy, cell death, and disease. Frontiers in bioscience (Landmark edition). 2016 Jan;21(1):42–54.
• Erratum. Autophagy. 2016;12(2):443.
• Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Vol. 12, Autophagy. 2016. p. 1–222.
• Maurer LL, Ryde IT, Yang X, Meyer JN. Caenorhabditis elegans as a Model for Toxic Effects of Nanoparticles: Lethality, Growth, and Reproduction. Current protocols in toxicology. 2015 Nov;66:20.10.1-20.10.25.
• Luz AL, Smith LL, Rooney JP, Meyer JN. Seahorse Xfe 24 Extracellular Flux Analyzer-Based Analysis of Cellular Respiration in Caenorhabditis elegans. Current protocols in toxicology. 2015 Nov;66:25.7.1-25.7.15.
• Gorka DE, Osterberg JS, Gwin CA, Colman BP, Meyer JN, Bernhardt ES, et al. Reducing Environmental Toxicity of Silver Nanoparticles through Shape Control. Environmental science & technology. 2015 Aug;49(16):10093–8.
• Robey RB, Weisz J, Kuemmerle NB, Salzberg AC, Berg A, Brown DG, et al. Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis? Carcinogenesis. 2015 Jun;36 Suppl 1:S203–31.
• Jayasundara N, Van Tiem Garner L, Meyer JN, Erwin KN, Di Giulio RT. AHR2-Mediated transcriptomic responses underlying the synergistic cardiac developmental toxicity of PAHs. Toxicological sciences : an official journal of the Society of Toxicology. 2015 Feb;143(2):469–81.
• Bone AJ, Matson CW, Colman BP, Yang X, Meyer JN, Di Giulio RT. Silver nanoparticle toxicity to Atlantic killifish (Fundulus heteroclitus) and Caenorhabditis elegans: a comparison of mesocosm, microcosm, and conventional laboratory studies. Environmental toxicology and chemistry. 2015 Feb;34(2):275–82.
• Rooney JP, Ryde IT, Sanders LH, Howlett EH, Colton MD, Germ KE, et al. PCR based determination of mitochondrial DNA copy number in multiple species. Methods Mol Biol. 2015;1241:23–38.
• Luz AL, Rooney JP, Kubik LL, Gonzalez CP, Song DH, Meyer JN. Mitochondrial Morphology and Fundamental Parameters of the Mitochondrial Respiratory Chain Are Altered in Caenorhabditis elegans Strains Deficient in Mitochondrial Dynamics and Homeostasis Processes. PloS one. 2015 Jan;10(6):e0130940.
• Shaughnessy DT, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, et al. Mitochondria, energetics, epigenetics, and cellular responses to stress. Environ Health Perspect. 2014 Dec;122(12):1271–8.
• Sendoel A, Maida S, Zheng X, Teo Y, Stergiou L, Rossi C-A, et al. DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis. Nature cell biology. 2014 Aug;16(8):812–20.
• Rooney JP, Luz AL, González-Hunt CP, Bodhicharla R, Ryde IT, Anbalagan C, et al. Effects of 5'-fluoro-2-deoxyuridine on mitochondrial biology in Caenorhabditis elegans. Experimental gerontology. 2014 Aug;56:69–76.
• Colton MD, Kwok KWH, Brandon JA, Warren IH, Ryde IT, Cooper EM, et al. Developmental toxicity and DNA damage from exposure to parking lot runoff retention pond samples in the Japanese medaka (Oryzias latipes). Marine environmental research. 2014 Aug;99:117–24.
• Ahn J-M, Eom H-J, Yang X, Meyer JN, Choi J. Comparative toxicity of silver nanoparticles on oxidative stress and DNA damage in the nematode, Caenorhabditis elegans. Chemosphere. 2014 Aug;108:343–52.
• Levard C, Yang X, Meyer JN, Lowry GV. Response to comment on "sulfidation of silver nanoparticles: Natural antidote to their toxicity". Environmental Science and Technology. 2014 May 20;48(10):6051–2.
• Yang X, Jiang C, Hsu-Kim H, Badireddy AR, Dykstra M, Wiesner M, et al. Silver nanoparticle behavior, uptake, and toxicity in Caenorhabditis elegans: effects of natural organic matter. Environmental science & technology. 2014 Mar;48(6):3486–95.
• González-Hunt CP, Leung MCK, Bodhicharla RK, McKeever MG, Arrant AE, Margillo KM, et al. Exposure to mitochondrial genotoxins and dopaminergic neurodegeneration in Caenorhabditis elegans. PloS one. 2014 Jan;9(12):e114459.
• Choi J, Tsyusko OV, Unrine JM, Chatterjee N, Ahn JM, Yang X, et al. A micro-sized model for the in vivo study of nanoparticle toxicity: What has Caenorhabditis elegans taught us? Environmental Chemistry. 2014 Jan 1;11(3):227–46.
• Rand AA, Rooney JP, Butt CM, Meyer JN, Mabury SA. Cellular toxicity associated with exposure to perfluorinated carboxylates (PFCAs) and their metabolic precursors. Chemical research in toxicology. 2014 Jan;27(1):42–50.
• Furda A, Santos JH, Meyer JN, Van Houten B. Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. Methods in molecular biology (Clifton, NJ). 2014 Jan;1105:419–37.
• Bodhicharla R, Ryde IT, Prasad GL, Meyer JN. The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces mitochondrial and nuclear DNA damage in Caenorhabditis elegans. Environmental and molecular mutagenesis. 2014 Jan;55(1):43–50.
• Rooney JP, Bodhicharla R, Bess AS, Leung MCK, Ryde IT, Ji AQ, et al. Developmental exposure to ultraviolet C radiation results in altered energy production later in life in Caenorhabditis elegans. Mitochondrion. 2013 Nov;13(6):922–922.
• Arnold MC, Badireddy AR, Wiesner MR, Di Giulio RT, Meyer JN. Cerium oxide nanoparticles are more toxic than equimolar bulk cerium oxide in Caenorhabditis elegans. Archives of environmental contamination and toxicology. 2013 Aug;65(2):224–33.
• Leung MCK, Rooney JP, Ryde IT, Bernal AJ, Bess AS, Crocker TL, et al. Effects of early life exposure to ultraviolet C radiation on mitochondrial DNA content, transcription, ATP production, and oxygen consumption in developing Caenorhabditis elegans. BMC pharmacology & toxicology. 2013 Feb;14:9.
• Meyer JN, Leung MCK, Rooney JP, Sendoel A, Hengartner MO, Kisby GE, et al. Mitochondria as a target of environmental toxicants. Toxicological Sciences. 2013;134(1):1–17.
• Bess AS, Ryde IT, Hinton DE, Meyer JN. UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts. Journal of biochemical and molecular toxicology. 2013 Jan;27(1):28–41.
• Levard C, Hotze EM, Colman BP, Dale AL, Truong L, Yang XY, et al. Sulfidation of silver nanoparticles: natural antidote to their toxicity. Environmental science & technology. 2013 Jan;47(23):13440–8.
• Bess AS, Leung MCK, Ryde IT, Rooney JP, Hinton DE, Meyer JN. Effects of mutations in mitochondrial dynamics-related genes on the mitochondrial response to ultraviolet C radiation in developing Caenorhabditis elegans. Worm. 2013 Jan;2(1):e23763.
• Turner EA, Kroeger GL, Arnold MC, Thornton BL, Di Giulio RT, Meyer JN. Assessing different mechanisms of toxicity in mountaintop removal/valley fill coal mining-affected watershed samples using Caenorhabditis elegans. PloS one. 2013 Jan;8(9):e75329.
• Meyer JN, Bess AS. Involvement of autophagy and mitochondrial dynamics in determining the fate and effects of irreparable mitochondrial DNA damage. Autophagy. 2012 Dec;8(12):1822–3.
• Brar SS, Meyer JN, Bortner CD, Van Houten B, Martin WJ. Mitochondrial DNA-depleted A549 cells are resistant to bleomycin. American journal of physiology Lung cellular and molecular physiology. 2012 Sep;303(5):L413–24.
• Furda AM, Bess AS, Meyer JN, Van Houten B. Analysis of DNA Damage and Repair in Nuclear and Mitochondrial DNA of Animal Cells Using Quantitative PCR. In: Methods in Molecular Biology. Humana Press; 2012. p. 111–32.
• Meyer JN. A call for fuller reporting of toxicity test data (Accepted). Integrated Environmental Assessment and Management. 2012;
• Meyer JN. In vivo analysis of the ability of Caenorhabditis elegans to metabolize the human CYP3A and CYP1A2 diagnostic substrates testosterone and phenacetin (Accepted). Worm Breeder’s Gazette. 2012;
• Furda AM, Bess AS, Meyer JN, Van Houten B. Analysis of DNA damage and repair in nuclear and mitochondrial DNA of animal cells using quantitative PCR. Methods in molecular biology (Clifton, NJ). 2012 Jan;920:111–32.
• Kasiviswanathan R, Gustafson MA, Copeland WC, Meyer JN. Human mitochondrial DNA polymerase gamma exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers. J Biol Chem. 2012;287(12):9222–9.
• Hunter SE, Gustafson MA, Margillo KM, Lee SA, Ryde IT, Meyer JN. In vivo repair of alkylating and oxidative DNA damage in the mitochondrial and nuclear genomes of wild-type and glycosylase-deficient Caenorhabditis elegans. DNA Repair (Amst). 2012;11(11):857–63.
• Bess AS, Crocker TL, Ryde IT, Meyer JN. Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans. Nucleic Acids Research. 2012;40(16):7916–31.
• Bess AS, Crocker TL, Ryde IT, Meyer JN. Mitochondrial Dynamics and Autophagy Aid in Removal of Persistent Mitochondrial DNA Damage. In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. WILEY-BLACKWELL; 2011. p. S47–S47.
• Yang X, Gondikas A, Marinakos S, Auffan M, Liu J, Hsu-Kim H, et al. The mechanism of silver nanoparticle toxicity is dependent on dissolved silver and surface coating in Caenorhabditis elegans (Accepted). Environmental Science & Technology. 2011;
• Meyer JN, Jung D, Di Giulio RT. Quantifying Mitochondrial and Nuclear DNA Damage in Sentinel Species. In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. WILEY-BLACKWELL; 2010. p. 702–702.
• Bess AS, Crocker TL, Meyer JN. Mitochondrial Fusion and Autophagy Aid in Removal of Helix-Distorting Mitochondrial DNA Damage. In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. WILEY-BLACKWELL; 2010. p. 716–716.
• Hunter SE, Jung D, Di Giulio RT, Meyer JN. The QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number. Methods (San Diego, Calif). 2010 Aug;51(4):444–51.
• Boamah EK, Brekman A, Tomasz M, Myeku N, Figueiredo-Pereira M, Hunter S, et al. DNA adducts of decarbamoyl mitomycin C efficiently kill cells without wild-type p53 resulting from proteasome-mediated degradation of checkpoint protein 1. Chemical research in toxicology. 2010 Jul;23(7):1151–62.
• Alexeyenko A, Wassenberg DM, Lobenhofer EK, Yen J, Linney E, Sonnhammer ELL, et al. Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity. PLoS One. 2010 May 5;5(5):e10465.
• Meyer JN. QPCR: a tool for analysis of mitochondrial and nuclear DNA damage in ecotoxicology. Ecotoxicology (London, England). 2010 Apr;19(4):804–11.
• Meyer JN, Van Houten B. Apparently normal DNA repair and transcript expression in the RB885 strain carrying an intronic deletion in the xpc-1 gene. Worm Breeder’s Gazette. 2010;18:23.
• Meyer JN, Lord CA, Yang XY, Turner EA, Badireddy AR, Marinakos S, et al. Intracellular uptake and associated toxicity of silver nanoparticles in Caenorhabditis elegans. Aquatic Toxicol. 2010;100:140–50.
• Leung MCK, Goldstone JV, Boyd WA, Freedman JH, Meyer JN. Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B1 but not benzo[a]pyrene in vivo. Toxicological Sciences. 2010;118:444–53.
• Alexeyenko A, Wassenberg DM, Lobenhofer EK, Yen J, Sonnhammer ELL, Linney E, et al. Interactome-based analysis of the transcriptomic response to dioxin in developing zebrafish Danio rerio. PLoS ONE. 2010;5:e10465.
• Boyd WA, Crocker TL, Rodriguez AM, Leung MC, Lehmann DW, Freedman JH, et al. Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure. Mutat Res. 2010;683(1–2):57–67.
• Haugen AC, Di Prospero NA, Parker JS, Fannin RD, Chou J, Meyer JN, et al. Altered gene expression and DNA damage in peripheral blood cells from Friedreich's ataxia patients: cellular model of pathology. PLoS genetics. 2010 Jan;6(1):e1000812.
• Alexeyenko A, Wassenberg DM, Lobenhofer EK, Yen J, Linney E, Sonnhammer ELL, et al. Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity. PloS one. 2010;5(5):e10465.
• Jung D, Cho Y, Meyer JN, Di Giulio RT. The long amplicon quantitative PCR for DNA damage assay as a sensitive method of assessing DNA damage in the environmental model, Atlantic killifish (Fundulus heteroclitus). Comparative biochemistry and physiology Toxicology & pharmacology : CBP. 2009 Mar;149(2):182–6.
• Eischeid AC, Meyer JN, Linden KG. UV disinfection of adenoviruses: molecular indications of DNA damage efficiency. Applied and environmental microbiology. 2009 Jan;75(1):23–8.
• Eischeid AC, Meyer JN, Linden KG. DNA damage assessment in UV-treated adenovirus. Water Quality Technology Conference and Exposition 2008. 2008 Dec 1;2968–75.
• Leung MCK, Williams PL, Benedetto A, Au C, Helmcke KJ, Aschner M, et al. Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. Toxicological sciences : an official journal of the Society of Toxicology. 2008 Nov;106(1):5–28.
• Billiard SM, Meyer JN, Wassenberg DM, Hodson PV, Di Giulio RT. Nonadditive effects of PAHs on Early Vertebrate Development: mechanisms and implications for risk assessment. Toxicological sciences : an official journal of the Society of Toxicology. 2008 Sep;105(1):5–23.
• Meyer JN, Arrant AE, Bernal AJ, Leung MC-K, Crocker TL. The use of c. elegans to study mitochondrial DNA damage, Fission/Fusion events and autophagy. In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. WILEY-BLACKWELL; 2008. p. 522–522.
• Jung D, Meyer JN, Di Giulio RT. Effects of polycyclic aromatic hydrocarbons on mitochondrial DNA damage in the killifish (Fundulus heteroclitus). MARINE ENVIRONMENTAL RESEARCH. 2008 Jul 1;66(1):32–32.
• Burnett KG, Bain LJ, Baldwin WS, Callard GV, Cohen S, Di Giulio RT, et al. Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics. Comparative biochemistry and physiology Part D, Genomics & proteomics. 2007 Dec;2(4):257–86.
• Wielgus AR, Chignell CF, Miller DS, Van Houten B, Meyer J, Hu D-N, et al. Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wort. Photochemistry and photobiology. 2007 May;83(3):706–13.
• Chan SSL, Santos JH, Meyer JN, Mandavilli BS, Cook DL, McCash CL, et al. Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination. Environmental and molecular mutagenesis. 2007 Apr;48(3–4):190–200.
• Meyer JN, Boyd WA, Azzam GA, Haugen AC, Freedman JH, Van Houten B. Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans. Genome biology. 2007 Jan;8(5):R70.
• Santos JH, Meyer JN, Van Houten B. Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. Human molecular genetics. 2006 Jun;15(11):1757–68.
• Santos JH, Meyer JN, Mandavilli BS, Van Houten B. Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. Methods in molecular biology (Clifton, NJ). 2006 Jan;314:183–99.
• Giulio RD, Billiard S, Meyer J, Wassenberg D, Hodson P. Synergistic developmental toxicity of polycyclic aromatic hydrocarbons: Towards a mechanistic understanding. In: Marine Environmental Research. 2006. p. S45–6.
• Timme-Laragy AR, Meyer JN, Waterland RA, Di Giulio RT. Analysis of CpG methylation in the killifish CYP1A promoter. Comparative biochemistry and physiology Toxicology & pharmacology : CBP. 2005 Aug;141(4):406–11.
• Meyer JN, Volz DC, Freedman JH, Di Giulio RT. Differential display of hepatic mRNA from killifish (Fundulus heteroclitus) inhabiting a Superfund estuary. Aquatic toxicology (Amsterdam, Netherlands). 2005 Jul;73(4):327–41.
• Santos JH, Meyer JN, Skorvaga M, Annab LA, Van Houten B. Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. Aging cell. 2004 Dec;3(6):399–411.
• Meyer JN, Boyd WA, Haugen AC, Freedman JH, Van Houten B. A caenorhabditis elegans model of Friedreich's ataxia shows iron sensitivity, mitochondrial DNA damage, and altered gene expression. In: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. WILEY-LISS; 2004. p. 215–215.
• Meyer JN, Smith JD, Winston GW, Di Giulio RT. Antioxidant defenses in killifish (Fundulus heteroclitus) exposed to contaminated sediments and model prooxidants: short-term and heritable responses. Aquatic toxicology (Amsterdam, Netherlands). 2003 Dec;65(4):377–95.
• Meyer JN, Wassenberg DM, Karchner SI, Hahn ME, Di Giulio RT. Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories. Environmental toxicology and chemistry. 2003 Oct;22(10):2337–43.
• Meyer JN, Di Giulio RT. Heritable adaptation and fitness costs in killifish (Fundulus heteroclitus) inhabiting a polluted estuary. Ecological Applications. 2003 Jan 1;13(2):490–503.
• Meyer J, Di Giulio R. Patterns of heritability of decreased EROD activity and resistance to PCB 126-induced teratogenesis in laboratory-reared offspring of killifish (Fundulus heteroclitus) from a creosote-contaminated site in the Elizabeth River, VA, USA. Marine environmental research. 2002 Sep;54(3–5):621–6.
• Meyer JN, Nacci DE, Di Giulio RT. Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments. Toxicological sciences : an official journal of the Society of Toxicology. 2002 Jul;68(1):69–81.
• Meyer JN, MacLean ED, Di Giulio RT. Increased sensitivity to oxidative stress in a creosote-adapted population of mummichog (Fundulus heteroclitus). Marine Environmental Research. 2000 Jan 1;50(1–5):78.
• Keller JM, Meyer JN, Mattie M, Augspurger T, Rau M, Dong J, et al. Assessment of immunotoxicology in wild populations: Review and recommendations. Reviews in Toxicology. 1999 Dec 1;3(1–4):167–212.
• Weintraub ER. Introduction. In: Weintraub ER, editor. Toward a History of Game Theory. Durham and London: Duke University Press; 1992. p. 3–12.